A SINGLE DOSE OF RECOMBINANT HUMAN IGF-I (rhIGF-I) DOES NOT AFFECT URINARY EXCRETION OF NITRIC OXIDE METABOLITES IN IDDM. 560

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

IGF-I does not affect the net increase in GH release in response to arginine.

Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin (SS) release. Insulin-like growth factor I (IGF-I) inhibits GH secretion via effects at the pituitary and/or hypothalamus. We hypothesized that if the dominant action of IGF-I is to suppress GH release at the level of the pituitary, then the arginine-induced net increase in GH concentration would...

متن کامل

The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants

Introduction: Biochemical markers play an important role in the growth and repair of bone and can be evaluated in different biological fluids. Therefore, the aim of this study was to evaluate the level of insulin-like growth factor-I (IGF-I) in urine as a puberty index and to compare it with cervical vertebral maturational stages (CVMSs) in lateral cephalometry. Materials&Methods: In this cros...

متن کامل

Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression.

The insulin-like growth factors (IGF) I and II regulate metabolism, mitogenesis, differentiation, and apoptosis. The therapeutic uses of IGF-I have been discussed extensively; however, excessive activity of the IGF ligands and IGF-I receptor has been suggested as a factor in tumorigenesis. The inhibition of apoptosis by IGF-I is believed to be particularly important for the stimulation of tumor...

متن کامل

Nitric Oxide–dependent Actions of IGF-I on Human Skeletal Muscle Metabolism

In human skeletal muscle, insulin-like growth factor-I (IGF-I) exerts both growth hormone–like (increase in protein synthesis) and insulin-like (decrease in protein degradation and increase in glucose uptake) actions and augments forearm blood flow twoto threefold. This study was designed to address whether ( a ) the increase in blood flow due to IGF-I could be blocked by an inhibitor of nitric...

متن کامل

Increasing of serum nitric oxide metabolites in chicken Eimeria infection

In order to determine the involvement of nitric oxide in the pathogenesis of coccidiosis induced by Eimeria, 30 chickens were challenged with mixed sporulated oocysts of four species of Eimeria (E. acervulina, E. maxima, E. necatrix, and E. tenella) at 26 days of age. There was an increasing of oocyst shedding in the infected birds at 6, 10 and 14 days post-infection. Histopathological examinat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Pediatric Research

سال: 1996

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199604001-00581